en فرایند اطلاعاتی و مهندسی Information Processing and Engineering پژوهشي Research Health care centers as an important part of health care industry, in addition to following their major mission, that is, providing high quality health service, can gain environmental and even socioeconomic advantages through reducing environmental effects resulted from their activities. With the goal of gaining these advantages, health care centers can increase their environmental performance through adopting a systematic and proper approach in application of information systems (ISs). The Green information systems (ISs) that indicate a novice approach in application of ISs are considered as necessary tools to realize the goals of environmental sustainability. Different factors affect Green ISs adoption by health care centers. In this research, these factors were first identified through library method and review of the literature. Then, the relationships between these factors were analyzed and modeled using interpretive structural approach. According to the results, the volume of social investment, research and development along with the senior management’s insight and commitment are the most important factors affecting Green ISs adoption in the health care centers. Health care centers, Green information system (IS), Interpretive Structural Modeling (ISM) 321 341 http://ijiepr.iust.ac.ir/browse.php?a_code=A-10-947-2&slc_lang=en&sid=1 Hossein Sayyadi Tooranloo h.sayyadi@vru.ac.ir 180031947532846005541 180031947532846005541 Yes Assistant Professor of Management Faculty, Vali-e-Asr University of Rafsanjan Sajad Rahimi sajad.management@yahoo.com 180031947532846005542 180031947532846005542 No Master science of Management, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran